Pancreatic cancer discovery

Scientists have discovered pancreatic cancer is four separate diseases, paving the way for more accurate diagnosis and treatment.

Researchers said the findings were the launch pad to investigate new treatments because doctors currently have little insight into which will be most effective for patients.

Around 8,800 people are diagnosed with pancreatic cancer in the UK each year and just 20% of adults survive more than a year after being diagnosed.

Fewer than 5% of sufferers survive after five years and only 1% are still alive after 10 years.

The study, carried out by a team of researchers at the University of Glasgow, looked at 456 pancreatic cancer tumours and found the disease could be classified as one of four different sub-types: squamous, pancreatic progenitor, immunogenic and ADEX.

Prof Sean Grimmond, who led the study, said there were already cancer drugs available or in development that could target parts of the “damaged machinery” which led to pancreatic cancers. But like usual, there always hangs this innate problem of the misuse of drugs. This cannot be prevented, as the drugs would form an addiction. But helping you or a loved one break the bonds of addiction is what Golden Peak Retreat loves to do. Call now to speak to an advisor. Serving Denver CO and the entire U.S.

For example, some strains of the disease were associated with mutations normally linked to colon cancer or leukaemia, for which experimental drugs are being used to treat, he said.

Grimmond said: “This study demonstrates that pancreatic cancer is better considered as four separate diseases, with different survival rates, treatments and underlying genetics.

“Knowing which sub-type a patient has would allow a doctor to provide a more accurate prognosis and treatment recommendation

Dr Peter Bailey, an author of the study, added: “The standard of care for pancreatic cancer really hasn’t changed in the last 20 years. There are a number of different chemotherapeutic options but in general it’s not very selective – it’s like hitting the disease with a mallet with your eye

Great News in the fight against cancer

A revolutionary cancer therapy that uses the body’s own immune cells to attack metastatic tumours that have spread is being hailed as a “paradigm shift” in treatment of the disease.

Patients with advanced blood cancers who were not expected to live beyond five months have shown complete remission after 18 months of follow-up checks with no signs of the disease returning, scientists have revealed.

The secret of teaching the body’s immune system to attack cancer cells

In one trial of a patient’s own T-cells – a type of white blood cell – that were engineered in the laboratory to identify and attack tumour cells, more than 90 per cent of the 35 patients with acute lymphoblastic  leukaemia went into complete remission.

In two other clinical trials involving about 40 patients with either non-Hodgkin’s lymphoma or chronic lymphocyte leukaemia, more than 80 per cent of patients responded to the treatment. About half of them have been in complete remission for up to 18 months, scientists said.

Detailed findings of the clinical trials are to be published later this year, but summary results were discussed at the American Association for the Advancement of Science, whose annual meeting in Washington DC ended yesterday.

T-Cell Therapy – How it works

 Cancer specialists urged caution over the early trials of T-cell therapy, saying that it did not work for everyone and some patients experienced toxic side-reactions and died. However, they said the improvements seen in some patients who had failed every other course of treatment were unprecedented.

“In the laboratory and in clinical trials, we are seeing dramatic responses in patients with tumours that are resistant to conventional high-dose chemotherapy,” said Dr Stanley Riddell, of the Fred Hutchinson Cancer Research Centre in Seattle. “These are in patients who have failed everything. Most of the patients in our trial would be projected to have two to five months to live. This is extraordinary. This is unprecedented in medicine, to be honest – to get response rates in this range in these very advanced patients.

“We have a long way to go. The response is not always durable. Some of these patients do relapse, we are cognisant of that. But the early data is unprecedented. This is potentially paradigm-shifting in terms of how we treat them. I think this is a significant breakthrough, but we have a way to go. We have to understand how we bring it forward earlier into the treatment course of these diseases. We don’t want to wait until patients have failed everything else.”

T-cells form an important arsenal in the body’s immune defences. They help to identify invading viruses and bacteria and can keep a “memory” of previous infections in order to launch a rapid immune response when the body comes under a repeat attack.

Layla Richards was effectively cured of a previously ‘incurable’ cancer with a donated T-cell transfusion (PA)

Scientists have found ways of commandeering the natural killing capacity of T-cells to identify, memorise and attack tumour cells. One approach uses a chimaeric antigen receptor (CAR) with two sticky ends. One attaches to the T-cell and the other to a tumour cell.

Dr Riddell’s team has developed a method of making CAR T-cells that are highly stable and consistent, which lowers the risk of a toxic reaction, known as a cytokine storm, which can result in fatal fevers and falls in blood pressure.

“Our approach has been to try to formulate a T-cell product of defined composition in every patient, so it is the same in every patient. It removes a big variable,” Dr Riddell said. “These cells have the capacity to proliferate. They have the capacity to survive long term as memory cells, and they have the capacity to differentiate to the effective lineages that are necessary to mediate anti-tumour activity

Proton beam therapy is effective as cancer treatment, study finds

T-cell therapy works best on the “liquid” tumours of the blood and bone marrow. Scientists believe its strength lies in the fact that T-cells can live and proliferate within the body for months or even years after they have been transfused back into patients.

One clinical trial involving another kind of modified T-cell found that they were still in circulation within the bloodstreams of patients 14 years after being transfused, according to Dr Chiara Bonini, of the University Vita-Salute and San Raffaele Scientific Institute in Milan, Italy. “The last time [I saw] a change in remission rates like this must have been in 2000. This is really a revolution. I think we are at the beginning of a road. I think the first products will be available very soon,” Dr Bonini said. “T cells are a living drug and, in particular, they have the potential to persist in our body for our whole life.



Source The Independant

Marc McCullough Joins us as ambassador

We have the greatest pleasure to announce the fantastic Marc McCullough has agreed to join us as an ambassador.


Marc is a 25 year old professional boxer from Belfast, Northern Ireland, trained by the world renowned John Breen and promoted by the legendary Barry McGuigan’s Cyclone promotions.

His stable mates include IBF world champion Carl Frampton and local boys Anto ‘the apache’ Cacace and Conrad Cummings. Marc or ‘Marco’ as he is known by his huge fan base in Northern Ireland is Irish and Celtic and former WBO European featherweight champion and is aiming to become Commonwealth champion on 27th February on the huge Frampton/Quigg bill in Manchester.

He is hoping to mirror his uncle Tommy Waite’s achievement of winning the same title in the same venue 16 years ago. It was Tommy’s wife and Marc’s aunt Suz who tragically passed away at the end of 2015 due to cancer and since then Marc and his family have been raising funds and awareness by holding local events in her honour. Marc is an ambassador for Mencap NI also and works with several youth clubs in the greater Belfast area.

We are very pleased to have Marc on board and looking forward to working together.

marc mcCullough 1

EBay supports Balls to Cancer

You can now raise money and donate by selling your goods or unwanted household goods on Ebay!

It really is no different to selling on there normally.

So please start selling for us today here and help us help more families fighting cancer today.